Histological changes induced by Piroxicam on the hepatic and renal tissues of mice with and without administration of Peppermint oil

Abstract Piroxicam is a popular anti-inflammatory drug that displays palliative and antipyretic activity. Peppermint oil common flavoring used in foods drinks. To investigate the defensive action of against hepatic renal histological damage induced by mice. Forty healthy adult Swiss albino mice both sexes were categorized into 4 groups (10 each group): Control group (I); Treatment (II) – injected with 0.3 mg/kg/rat/day via intraperitoneal route for 28 days; (III) oral 0.2 ml/kg/day gavage 24 hours preceding injection Piroxicam; (IV) alone. Blood samples withdrawn to estimate functions. Immediately after death, specimens liver kidney from four isolated put 10% concentration buffered formalin then prepared light microscopic examination. There was highly significant rise serum level enzymes (alanine aminotransferase, aspartate aminotransferase alkaline phosphatase total bilirubin) treated Piroxicam, as compared control group. These returned near normal oil. Liver showed ballooning degeneration hepatocytes, small apoptotic hepatocytes inflammatory cellular infiltration, whereas sections revealed cystic dilatation Bowman’s space, shrinkage glomerular tuft apoptosis epithelial cells lining tubules. In contrast, addition peppermint efficiently ameliorated tissue changes. induces hepatorenal toxicity exhibited histological, histochemical biochemical findings. shows ameliorative properties toxic effects Piroxicam.